I work with 9 different tipes of PC, laptops, 32 bit and 64, it work on every type.
The problems appear when you plug in the interface, install it with disk, and after that you disconnect the interface. That generate a error and lasers don't work from this moment, it is necessary to reinstall it. Or try to not disconnect the interface from the PC in work.
I don't know if your problems appear from the cause described in bottom, in my AMD64 with Windows 7 all is ok. I install from the original disc version.